Health and hygiene in the process of human historical evolution since ancient times have been raised as an issue that societies have always interacted with, so that the health and well-being of the people of a city is an important indicator to show the success rate of sustainable development policies of that city. . The present study was conducted with the aim of investigating the spatio-temporal distribution of brain, nervous and mental diseases in Ardabil city. The current research is of an applied type and the method of carrying out descriptive-analytical research. The method of gathering information is based on documentary and field sources (private neurology and mental clinics). The community and the research space are all neuropsychiatric patients in Ardabil city, of which 699 patients were studied. that there are seven types of brain and nerve diseases in the time frame of 1399 to 1401, the findings indicate that the highest amount of disease is assigned to the year 1401, in the 3-year period, all diseases have doubled, which shows the increase of disorders Psychologist is in Ardabil city. According to the findings of the research, according to the gender, the most diseases were among women, and according to the type of disease, the most common diseases are depression, epilepsy and convulsions. According to the analysis of hot and cold spots in area (1), as one of the central areas of the city, it is the center of brain and nervous and mental diseases in Ardabil. Also, based on the Kernel density estimation model, region (1) is the main center of diseases, which affects the nearby areas of other regions, and it is visible in region 2, which is located in the neighborhood of region 1.