One of the key goals of locating urban catalyst projects is to achieve urban regeneration. Therefore, developing effective strategies and spatial patterns for the placement of such projects is essential, particularly in deteriorated areas such as historical fabrics. The main objective of this study is to evaluate the dimensions influencing the spatial pattern selection of catalyst development projects with an urban regeneration approach in the historical fabric of Khoy. This is an applied research conducted using a descriptive-analytical method. Data were collected through questionnaires and direct observation, and analyzed using the MARCOS-ANP method in Excel. In this study, various models for locating catalyst development projects—including Urban Catalyst Group, Stalker, Urban Acupuncture, Sternberg, Pop-up Urbanism, and Tactical Urbanism—were assessed against socio-cultural, economic, managerial, and physical-spatial factors. The findings indicate that selecting an appropriate model for catalyst project placement in historical contexts requires not only socio-economic and managerial analysis but also a deep understanding of spatial-physical capacities and environmental design. According to the results, the Stalker model (0.665), Urban Catalyst Group (0.649), Sternberg (0.648), Urban Acupuncture (0.629), Tactical Urbanism (0.528), and Pop-up Urbanism (0.473) are, in descending order, the most suitable models for implementing catalyst projects in the historical context of the case study. Hence, the Stalker and Urban Catalyst Group models are identified as the most appropriate for the historical fabric of Khoy. The Stalker model prioritizes activity over land use, emphasizes collective events, and promotes community participation. Meanwhile, the Urban Catalyst Group model highlights temporary functions. Finally, three locations with religious, commercial, and educational functions were identified for project implementation. It is concluded that catalyst development projects should be guided by models that integrate physical, social, economic, and managerial components to ensure project success and community acceptance.