The acceleration of urbanization and the growth of building energy consumption, accounting for nearly 36% of Iran’s energy use, have led to carbon emissions, air pollution, and the intensification of the urban heat island effect, revealing the need to reconsider architectural design approaches. In this context, biophilic design, as a nature-based and passive approach, strengthens the human–nature connection in the built environment, offering a proactive response to these challenges; by improving indoor air quality, natural ventilation, and sensory comfort, it aligns with sustainable architecture. However, evaluating the success of green buildings solely through technical and energy criteria is insufficient, and residents’ satisfaction and well-being constitute an essential indicator. The present study aimed to analyze global research trends in biophilic design from 2020 to 2025 through bibliometric analysis. Data were gathered from Web of Science and, after applying filters, 1,633 scientific documents were analyzed using VOSviewer. Co-authorship, co-citation, bibliographic coupling, and keyword co-occurrence analyses showed that this field has followed an upward trend, reaching its peak scientific output in 2024; Sustainability and Tampere University led in publication and research output, while the United States, China, and Australia rank among the most active countries. Keyword clustering revealed twelve thematic clusters, ranging from theoretical foundations and technologies to mental health and urban policy. The findings indicate that biophilic design is a maturing yet dynamic field whose future is moving toward the convergence of human-centered and technology-driven research, artificial intelligence, and physiological measurements—a path that could establish it as a measurable standard in urban policy and building regulations.